NS3
NS3 (short for nohouseisenishyou) is an extremely rare terminal illness with no known cause. It's aggressive ability to damage and destroy internal organs results in an extremely short and painful life expectancy once the disease manifests.
Cause
The exact cause of NS3 is unknown, however most classify it as a non-inheritable genetic disorder. Symptoms generally appear without warning in the mid-to-late 20's, though the youngest confirmed diagnosis was only eight years old. The only acknowledged common trait among all carriers is that they were, in some fashion, shinobi, which causes some to speculate that the disease is triggered by a chakra-induced mutation of a genome. Others disagree with classifying all confirmed patients under the umbrella of one disease, due to the difference in family history, location, gender, age and bloodlines.
Symptoms
Once the symptoms of NS3 have manifested, the illness progresses rapidly with a life expectancy less than one year. The disorder causes an almost autoimmunity like response as vital organs begin to aggressively deteriorate, especially the heart, lungs, liver, and kidneys. It can also causes severe damage to tenketsu pathways, making it difficult if not impossible to mold chakra. Brain function is relatively unaffected, however mental duress due to pain or other stress factors is common.
Cardiovascular System
Digestive System
Nausea is a common complaint from those with NS3 due to difficulty metabolizing food and liquids, resulting in little to no appetite.
Other Signs and Symptoms
Treatment
There is no known cure for NS3, and due to the damage that is done to the internal organs it can be very difficult to treat. The deterioration of the kidney and liver makes it difficult to metabolize most common medicines, and further complications with the digestive and cardiovascular system means that most recipients experience side effects that are as bad, or worse, than the symptoms they are trying to combat. Because the illness is terminal, medics primarily focus on palliative care so the patient can maintain as much of their quality of life as possible.